Helical gram-negative rod.
Enzyme produced is urease, which splits urea. Resulting bicarbonate creates alkaline environment. Another enzyme mucinase degrades mucus.
Lives only in gastric epithelium.
Injury is due to:
- Toxins such as vacuolating cytotoxin increased gastrin levels
- Platelet-activating factor
- Increased immunoglobulin response (host response)
- Local tissue injury
- Local ischaemia
Remember as HELlCO
© Manipal manual of surgery, fourth edition