Posted in Pathology

Mechanism of Helicobacter Pylori induced injury-Summary

Helical gram-negative rod.

Enzyme produced is urease, which splits urea. Resulting bicarbonate creates alkaline environment. Another enzyme mucinase degrades mucus. 

Lives only in gastric epithelium.
Injury is due to: 

  • Toxins such as vacuolating cytotoxin increased gastrin levels 
  • Phospholipases 
  • Platelet-activating factor 
  • Increased immunoglobulin response (host response) 


Other factors 

  • Local tissue injury 
  • Local ischaemia 

Remember as HELlCO 

© Manipal manual of surgery, fourth edition

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